TNIP2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comTNIP2 Polyclonal Antibody for Human(Homo sapiens)

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TNIP2 (Gene name),

TNFAIP3-interacting protein 2 (Protein name ), TNIP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TNIP2(ABIN2;FLIP1);

Protein name:

TNFAIP3-interacting protein 2;

Alternative:

Fetal liver LKB1-interacting protein;A20-binding inhibitor of NF-kappa-B activation 2(ABIN-2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8 and RIPK1.

Function:

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

429

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

429:

GDLQCPHCLQ | CFSDEQGEEL | LRHVAECCQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:79155

Pfam:

PF12180

UniGene:

Hs.726088

MIM:

610669

SMR:

Q8NFZ5

STRING:

9606.ENSP00000321203

UniGene:

Hs.368551

String:

Q8NFZ5

Uniprot:

Q8NFZ5

FOR

ELISA Kit for Human TNFAIP3-interacting protein 2

Cat.:

E15525h

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MSDS:

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Packing:

96T

ELISA Kit for Human TNFAIP3-interacting protein 2

Cat.:

E15525m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TNFAIP3-interacting protein 2

Cat.:

U15525m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TNFAIP3-interacting protein 2

Cat.:

U15525h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human TNFAIP3-interacting protein 2

Cat.:

P15525Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TNFAIP3-interacting protein 2

Cat.:

P15525Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human TNFAIP3-interacting protein 2

Protein for Human TNFAIP3-interacting protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Identification of a novel A20-binding inhibitor of nuclear factor-kappaB activation termed ABIN-2."
Van Huffel S.C. , Delaei F. , Heyninck K. , De Valck D. , Beyaert R.
J. Biol. Chem.276:30216-30223(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation."
Liu W.-K. , Chien C.-Y. , Chou C.-K. , Su J.-Y.
J. Biomed. Sci.10:242-252(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH STK11/LKB1
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT VAL-396
tissue: Kidney epithelium.
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-396
tissue: Uterus.
7.

"Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions."
Klinkenberg M. , Van Huffel S. , Heyninck K. , Beyaert R.
FEBS Lett.498:93-97(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFAIP3
8.

"ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1."
Tadros A. , Hughes D.P. , Dunmore B.J. , Brindle N.P.
Blood102:4407-4409(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2."
Hughes D.P. , Marron M.B. , Brindle N.P.
Circ. Res.92:630-636(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TEK
10.

"The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation."
Chien C.Y. , Liu W.K. , Chou C.K. , Su J.Y.
FEBS Lett.543:55-60(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SMARCD1
11.

"The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis."
Liu W.-K. , Yen P.-F. , Chien C.-Y. , Fann M.-J. , Su J.-Y. , Chou C.-K.
Biochem. J.378:867-876(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IKBKG
12.

"ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
Lang V. , Symons A. , Watton S.J. , Janzen J. , Soneji Y. , Beinke S. , Howell S. , Ley S.C.
Mol. Cell. Biol.24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKB1; MAP3K8 AND TNFAIP3
13.

"Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins."
Wagner S. , Carpentier I. , Rogov V. , Kreike M. , Ikeda F. , Lohr F. , Wu C.J. , Ashwell J.D. , Dotsch V. , Dikic I. , Beyaert R.
Oncogene27:3739-3745(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITIN-BINDING;MUTAGENESIS OF 309-ASP-PHE-310 AND 313-GLU-ARG-314
14.

"A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity."
Leotoing L. , Chereau F. , Baron S. , Hube F. , Valencia H.J. , Bordereaux D. , Demmers J.A. , Strouboulis J. , Baud V.
J. Biol. Chem.286:32277-32288(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CHUK AND IKBKB;UBIQUITINATION;PHOSPHORYLATION;MUTAGENESIS OF SER-62 AND SER-146
15.

"A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma."
Dong G. , Chanudet E. , Zeng N. , Appert A. , Chen Y.W. , Au W.Y. , Hamoudi R.A. , Watkins A.J. , Ye H. , Liu H. , Gao Z. , Chuang S.S. , Srivastava G. , Du M.Q.
Clin. Cancer Res.17:1440-1451(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-249 AND LYS-255;INTERACTION WITH TNFAIP3;CHARACTERIZATION OF VARIANT LYS-255

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